BDBM50187673 5-(3,3,6-trimethyl-indan-5-yloxy)-furan-2-carboxylic Acid [4,6-dimethoxy-2-(3-morpholin-4-yl-propylamino)-pyrimidine-5-yl]-amide::CHEMBL210514

SMILES COc1nc(NCCCN2CCOCC2)nc(OC)c1NC(=O)c1ccc(Oc2cc3c(CCC3(C)C)cc2C)o1

InChI Key InChIKey=IGTBNUVMBDYPQG-UHFFFAOYSA-N

Data  21 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50187673   

TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50187673(5-(3,3,6-trimethyl-indan-5-yloxy)-furan-2-carboxyl...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity to human recombinant GnRH receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50187673(5-(3,3,6-trimethyl-indan-5-yloxy)-furan-2-carboxyl...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity to rat pituitary GnRH receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50187673(5-(3,3,6-trimethyl-indan-5-yloxy)-furan-2-carboxyl...)
Affinity DataIC50:  3.30nMAssay Description:Antagonist activity at human recombinant GnRH receptor assessed as inhibition of GnRH-stimulated inositol phosphate accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50187673(5-(3,3,6-trimethyl-indan-5-yloxy)-furan-2-carboxyl...)
Affinity DataIC50:  8.80nMAssay Description:Antagonist activity at rat pitutary GnRH receptor assessed as inhibition of GnRH-stimulated inositol phosphate accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed